Pharmacokinetic changes: what the body does to the drug Pharmacokinetic changes: what the body does to the drug Pharmacokinetic is part of the pharmacology branches, which seeks to determine the fate that an externally administered substance has on a living organism. The most interesting substances in this subject comprise of toxins, nutrients, and hormones. Pharmacokinetics employs a scheme referred to as ADME, which divides this subject into a number of areas. These classes comprise of excretion, metabolism, distribution, and absorption. Substances such as toxins, hormones, and nutrients enter a human’s body through the process of absorption.
After absorption, distribution or dissemination follows where it takes the absorbed substances into the tissues and fluids of the human body. Thereafter, metabolism takes over and changes the parent compounds through an irreversible transformation into daughter metabolites. The final step that an externally administered substance mainly drugs is the excretion. Excretion partakes to eliminate or remove these substances from the human’s body. Drugs may affect the properties of pharmacokinetic through elements such as the administered dosage and the site of administration. Drugs injected into a human body intravenously leave the plasma via two first hand mechanisms.
In the first one, the body removes a drug by distributing it to the body tissues. In the second arena, the body removes a drug through metabolism and excretion. After these processes, the plasma of a drug decreases its concentration through the biphasic pattern. In conclusion, since the work of a drug is to alleviate symptoms or cure a certain disease. It passes several biological membranes while in the process of eradicating unwanted components in a human’s body. In the site of action, it crosses biological membranes by use of principle membranes such as filtration, facilitated or passive diffusion, and active transport.
Pharmacokinetic studies aid to our knowledge about the things that our bodies do to drugs that we take with the aim of curing or removing certain symptoms or even for other purposes. ReferencesBurchum, J. R. L. Pharmacologic management. Chapter 22.